Endocrine Abstracts

Introduction: Graves orbitopathy is the major extrathyroidal manifestation of Graves Disease (GD). The approach depends on its clinical activity and severity. Treatment and referral to specialized centers, with Endocrinology and Ophthalmology, has a strong impact on the prognosis of Graves’ Disease (GD) and GO.Cases report: We report four cases of DG with OG. Their characteristics and clinical evolution are shown in Table 1.<table boarder="1" ce...

Background: Obesity represents a cardiovascular risk factor. Monocyte chemoattractant protein-1 (MCP-1) is a known regulator of monocyte recruitment to sites of inflammation, and participates at the early phases of atherogenesis. Apolipoproteins, as part of the lipoprotein particles, are classically coupled with cardiovascular risk distinction.Aims: To assess the association of anthropometric parameters, insulin resistance and MCP-1 levels with classic l...

Background: Although acyl–ghrelin has been considered essential for ghrelin’s GH-releasing activity, several recent in vitro studies have shown that desacyl–ghrelin exhibits biological activities on metabolism and proliferation of adipocytes, myocytes, cardiomyocytes, and myelocytes. The full desacyl–ghrelin biological activity still remains a matter of debate.Aims: To assess desacyl–ghrelin circulating levels and its R51Q...

Background: Adiponectin is an adipokine with anti-diabetic properties. Recently, retinol binding protein-4 (RBP4) was identified as an adipokine associated with insulin resistance (IR) and a potential marker for type 2 diabetes (T2D) development.Aims: To compare adiponectin and RBP4 circulating levels according to presence/absence of diabetes/prediabetes, in obese women. To study the degree of association of those adipokines with indexes of IR and insuli...